When the Default is Not Enough: An Emergency Medicine Clinician's Guide to Novel Amyloid-Related Imaging Abnormalities in Alzheimer's Disease

March 25, 2024

Program Description

With the first approvals of amyloid-targeting therapies (ATTs) for patients with early Alzheimer’s disease (AD) neurobiology, the way this illness is viewed and managed is facing a paradigm shift. However, while disease-modifying therapies (DMTs) are a long-awaited breakthrough in the treatment of AD, ATTs have also introduced new, class specific adverse effects, amyloid-related imaging abnormalities (ARIA), with which most clinicians, regardless of specialty, have not yet come into contact, creating a host of novel considerations and potential practice changes. This lack of exposure and limited published guidance may be particularly problematic in emergency department (ED) settings which are likely to encounter the most urgent needs of those affected by ARIA.

This live virtual webinar focuses on emergency medicine clinicians' role in the recognition and acute management of ARIA, including how ARIA may present and what courses of action are needed for different ARIA severities.

Target Audience

The target audience for this activity includes emergency medicine physicians, neurologists, neuroradiologists, nurse practitioners, physician assistants, nursing staff, triage specialists, and other healthcare professionals (HCPs) specializing or consulting in the care of older adults in the ED.

Learning Objectives

Upon completion of the educational activity, participants should be able to:

  • Describe the range of symptoms of ARIA that may prompt a patient to seek emergency care and how to differentiate them from more common conditions to appropriately triage these individuals and determine next steps in their management
  • Isolate possible types of ARIA (ARIA-E, ARIA-H) as well as which do and do not require hospital admission/immediate treatment (e.g., corticosteroids) to effectively coordinate variable patient presentations
  •  Identify key areas of interdisciplinary communication that may impact a care team’s ability to successfully triage, diagnose, and/ or treat ARIA and employ corresponding solutions to maximize workflow efficiency and patient outcomes
  • Recognize which medications/treatments that may be administered in the ED are inappropriate or contraindicated in patients prescribed ATTs and strategize management protocols for clinical scenarios in which they would be utilized
Course summary
Course opens: 
Course expires: 
Event starts: 
03/25/2024 - 3:00pm EDT
Event ends: 
03/25/2024 - 4:00pm EDT

The Relevance of ATT and ARIA to the ED

  • Overview of amyloid-targeting therapies
  • Importance and challenges of accurate medical history in patients with cognitive impairment
  • Definitions, prevalence, and risk factors of ARIA-H and ARIA-E

Workflow Discussion and Q&A What changes have to happen in your ED to better recognize these therapies and their potential complications?


ARIA Recognition and Triage

  • Range of clinical presentations of ARIA that may be seen in the ED
  • Appropriate work-up for patients presenting with symptoms of ARIA and how that deviates from typical ED protocols
  • Differential diagnoses and ARIA mimics; what to communicate to the radiologist

Workflow Discussion and Q&A Workflow Example: roles and responsibilities.


Management of Patients on ATT

  • Categories of ARIA radiographical severity and their respective management strategies in the ED
  • Contraindicated medications and therapies for patients on ATT
  • Potential interventions that may be beneficial in certain presentations of ARIA
  • Candidates for discharge vs admission and corresponding plans

Workflow Discussion and Q&A Support for patients & caregivers: what to expect after discharge.

   Don Melady, MSc(Ed) MD
   Associate Professor, Faculty of Medicine
   University of Toronto
   Schwartz-Reisman Emergency Medicine Institute
   Toronto, Ontario Canada



   Kevin Biese, MD, MAT
   Vice-Chair, Academic Affairs Director
   Division Of Geriatric Emergency Medicine Clinical
   Associate Professor, Internal Medicine, Division Of Geriatrics
   Chapel Hill, NC



   Gloria Chiang, MD
   Vice Chair, Clinical and Translational Research
   Director, Brain Health Imaging Institute
   Associate Professor, Neuroradiology
   Department of Radiology
   Weill Cornell Medicine/NewYork-Presbyterian Hospital
   New York, NY


   Richard Isaacson, MD
   Director, Center for Brain Health,
   Schmidt College of Medicine
   Florida Atlantic University
   Boca Raton, FL



   Jennifer Sutherland, PharmD, BCEMP
   Emergency Medicine Clinical Pharmacy Specialist
   PGY2 Emergency Medicine Pharmacy Residency Program Director
   Assistant Adjunct Clinical Professor-Division of Practice Management and Clinical Education
   UNC Health | UNC Medical Center | UNC Eshelman School of Pharmacy
   Chapel Hill, NC

This activity is jointly provided by Medical Education Resources (MER) and Efficient LLC and was developed in partnership with the Geriatric Emergency Department Collaborative (GEDC).

image       image   

Joint Accreditation Statement


In support of improving patient care, this activity has been planned and implemented by Medical Education Resources (MER) and Efficient LLC. MER is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Designation Statement

Medical Education Resources designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Medical Education Resources has been authorized by the American Academy of Physician Assistants (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This  activity is designated for 1 AAPA Category 1 CME Credits.  Physician Assistants should only claim credit commensurate with the extent of their participation.
Medical Education Resources designates this live activity for a maximum of 1.0 ANCC nursing contact hours Nurses will be awarded contact hours upon successful completion of the activity.
A Certificate of Participation will be given upon completion of the enduring activity enabling participants to register their credit with the appropriate licensing boards or associations.

Disclosure of Relevant Financial Relationships

Medical Education Resources ensures balance, independence, objectivity, and scientific rigor in all our educational activities. In accordance with this policy, MER identifies relevant financial relationships with its instructors, content managers, and other individuals who are in a position to control the content of an activity. Reported relevant financial relationships are mitigated by MER to ensure that all scientific research referred to, reported, or used in an accredited continuing education activity conforms to the generally accepted standards of experimental design, data collection, and analysis. MER is committed to providing learners with high-quality accredited continuing education activities that promote improvements or quality in health care and not the business interest of an ineligible company.

Staff Disclosures

Efficient LLC and Medical Education Resources' planners and managers have no financial relationships to disclose.

Faculty Disclosures

Dr. Melady has no financial relationships to disclose

Dr. Biese reported the following financial relationships:

  • Speakers Bureau: Apogee Health staffing for geriatric providers in the ER/, Third Eye Telehealth for residents in SNFs

Dr. Chiang has no financial relationships to disclose

Dr. Isaacson reported the following financial relationships:

  • Consulting Fees: Acadia, Novo Nordisk

Dr. Sutherland has no financial relationships to disclose

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications. The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


The content and views presented in this educational activity are those of the authors and do not necessarily reflect those of Medical Education Resources, Efficient LLC, and/or Lilly. The authors have disclosed if there is any discussion of published and/or investigational uses of agents that are not indicated by the FDA in their presentations. Before prescribing any medicine, primary references and full prescribing information should be consulted. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities. The information presented in this activity is not meant to serve as a guideline for patient management.

Commercial Support

This activity is supported by an educational grant from Lilly. 

Method of Participation

There are no fees for participating in and receiving credit for this activity. During the period March 25, 2024 through March 25, 2025, participants must: 1) read the learning objectives and faculty disclosures, 2) complete the pre-and intra-activity assessment questions 3) participate in the live virtual activity, and 4) complete the evaluation form. 

A statement of credit will be issued only upon receipt of a completed activity evaluation form.




Please login or register to take this course.