Out of the Dark, Into the Light: Illuminating Modern Strategies for the Detection and Treatment of Bipolar Depression


Depression is the predominant presentation of bipolar disorder (BD), but it is easy to misdiagnose these patients with other psychiatric conditions if manic symptoms are not evident. Once an accurate BD diagnosis is obtained, there is then a complicated algorithm for pharmacotherapeutic management of depressive episodes. To help navigate diagnostic and management strategies for BD depression, this virtual adaptation of a traditional Grand Rounds brings experts straight to the clinical teams that manage these patients.

Target Audience

This activity is intended for psychiatrists, nurse practitioners, physician assistants and other healthcare professionals involved in the diagnosis and long-term management of patients with bipolar disorder.

Learning Objectives

Upon completion of the educational activity, participants should be able to:

  • Discuss preferred approaches to and indicators for BD depression as well as its differentiation from other psychiatric disorders (e.g., MDD) to diagnose these patients early and accurately
  • Evaluate the mechanisms of action, clinical profiles, and supporting phase 3 trial data for therapies with recent approvals for BD depression to effectively integrate these agents into clinical practice
  • Examine the role of antidepressants in BD and determine whether they may be used safely for certain patient presentations
Course summary
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Course expires: 


  Leslie Citrome, MD, MPH (Chair)
  Clinical Professor, Psychiatry and
  Behavioral Sciences
  New York Medical College
  Valhalla, NY



  Carmen Kosicek, MSN, APNP, PMHNP-BC
  CEO, Founder, Provider, Alay Health Team
  Tucson, AZ




  Joseph F. Goldberg, MD
  Professor of Psychiatry, Icahn School of Medicine at Mount Sinai
  New York, NY




  Craig Chepke, MD, FAPA
  Adjunct Associate Professor of Psychiatry, Atrium Health
  Adjunct Assistant Professor of Psychiatry, UNC School of Medicine
  Medical Director, Excel Psychiatric Associates
  Huntersville, NC
  Andrew J. Cutler, MD
  Clinical Associate Professor of Psychiatry
  SUNY Upstate Medical University
  Syracuse, NY



This activity is jointly provided by Medical Education Resources (MER) and Efficient LLC.

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Joint Accreditation Statement



In support of improving patient care, this activity has been planned and implemented by MER and Efficient, LLC. MER is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Designation Statement

MER designates this enduring activity for a maximum of 1.0 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Disclosure of Relevant Financial Relationships

MER insures balance, independence, objectivity, and scientific rigor in all our educational activities. In accordance with this policy, MER identifies relevant financial relationships with its instructors, content managers, and other individuals who are in a position to control the content of an activity. Reported relevant financial relationships are mitigated by MER to ensure that all scientific research referred to, reported, or used in a CE activity conforms to the generally accepted standards of experimental design, data collection, and analysis. MER is committed to providing learners with high-quality CE activities that promote improvements or quality in health care and not the business interest of an ineligible company.

Planners' and Managers' Disclosure
MER planners and managers have nothing to disclose. Efficient LLC planners and managers have nothing to disclose.

Faculty Disclosures

Dr. Citrome:

  • Contracted Research: AbbVie/Allergan, Acadia, Adamas, Alkermes, Angelini, Astellas, Avanir, Axsome, BioXcel, Boehringer Ingelheim, Cadent Therapeutics, Eisai, Enteris BioPharma, HLS Therapeutics, Impel, Intra-Cellular, Janssen, Karuna, Lundbeck, Lyndra, Medavante-ProPhase, Merck, Neurocrine, Novartis, Noven, Otsuka, Ovid, Relmada, Reviva, Sage, Sunovion, Teva, University of Arizona
  • Consulting Fees: AbbVie/Allergan, Acadia, Alkermes, Angelini, Eisai, Intra-Cellular, Janssen, Lundbeck, Neurocrine, Noven, Otsuka, Sage, Sunovion, Takeda, and Teva, 

Ms. Kosicek:

  • Consulting Fees: AbbVie, Boehringer Ingelheim, Corium, Eisai, Intra-Cellular, Teva
  • Speakers Bureau: AbbVie/Allergan, Alkermes, Intra-Cellular, Teva, US World Meds

Dr. Goldberg:

  • Consulting Fees: BioXcel, Jazz Pharmaceuticals, Lundbeck, Otsuka, Sage, Sunovion, Supernus
  • Speakers’ Bureau: AbbVie, Alkermes, Axsome, Intra-Cellular, Sunovion
  • Royalty: American Psychiatric Publishing; Cambridge Univ. Press

Dr. Chepke:

  • Contracted Research: Acadia, Axsome, Biohaven, Harmony, Neurocrine, Teva
  • Consulting Fees: AbbVie, Acadia, Alkermes, Axsome, BioXcel, Corium, Eisai, Genomind, Idorsia, Intra-Cellular, Ironshore, Janssen, Jazz, Karuna, Lundbeck, MedinCell, Neurocrine, Noven, Otsuka, Takeda, Teva; Advisory Board (spouse): Otsuka
  • Speakers’ Bureau: AbbVie, Acadia, Alkermes, Axsome, BioXcel, Corium, Eisai, Genomind, Idorsia, Intra-Cellular, Ironshore, Janssen, Jazz, Lundbeck, Merck, Neurocrine, Noven, Otsuka, Sunovion, Takeda, Teva

Dr. Cutler:

  • Consulting Fees:  AbbVie/Allergan, Acadia, Alfasigma, Alkermes, Axsome, Biogen, BioXcel, Boehringer Ingelheim, Cerevel, Corium, Intra-Cellular, Ironshore, Janssen, Jazz, Karuna, Lundbeck, Luye Pharma, Neumora/BlackThorn, Neurocrine, Noven, Otsuka, Relmada, Reviva Pharmaceuticals, Sage Therapeutics, Sunovion, Supernus, Takeda, Teva, Tris Pharma, VistaGen
  • Speakers’ Bureau:  AbbVie/Allergan, Acadia, Alfasigma, Alkermes, BioXcel, Corium, Intra-Cellular, Ironshore, Janssen, Lundbeck, Neurocrine, Noven, Otsuka, Sunovion, Supernus, Takeda, Teva, Tris Pharma
  • Employee & Board Member:  Neuroscience Education Institute

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications. The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient's conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer's product information, and comparison with recommendations of other authorities.

Commercial Support

This activity is supported by an educational grant from Intra-Cellular Therapies. 


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