Module 2: Initiation and Selection of Disease Modifying Therapy

This module will focus on key clinical factors and practical considerations that may impact DMT initiation as well as utilization of the diverse agents available. Factors discussed include age, radiologic versus clinical disease activity, and usefulness of distinguishing between MS categories. It will shed light on how well long-held theories have withstood the test of time and help to provide deeper insight into how experts are approaching the contemporary management of MS.

Target Audience

This activity is intended for neurologists, nurse practitioners, physician assistants, pharmacists, and other providers involved in the care of patients with MS.

Learning Objectives

  • Describe how to utilize clinical factors (e.g. age of onset, disease status) to accurately risk stratify individuals diagnosed with MS, and use this information in designing an appropriate management plan.
  • Appraise available research data on the risks and benefits associated with the use of "induction" versus "'escalation" approaches to the integration of disease modifying therapy (DMT) and consider this information when counseling patients with MS regarding available treatment options.

  Robert Bermel, MD
  Staff Neurologist and
  Director, Mellen Center for Multiple Sclerosis
  Cleveland Clinic
  Cleveland, Ohio
Dr. Bermel is a board certified neurologist and the director of the Mellen Center for Multiple Sclerosis (MS) at the Cleveland Clinic. He is widely recognized for his contributions to the field of neurology with a particular focus on MS research. He is actively involved at the forefront of pharmacological and technological advancement in MS and has been a frequent presenter of such advances at ACTRIMS and ECTRIMS as well as a consulting authority throughout the field.
  James Stankiewicz, MD
  Assistant Professor of Neurology
  Harvard Medical School
  Clinical Director, Partners Multiple Sclerosis Center
  Boston, Massachusetts
Dr. Stankiewicz is an assistant professor of neurology at Harvard Medical School and the clinical director for the Partners Multiple Sclerosis Center. He is involved in both medical and charitable endeavors among the MS community with current positions serving as topic co-chair at the American Academy of Neurology's annual meeting for MS and CNS Inflammatory Disease as well as on the medical advisory board of The Assistance Fund. He additionally co-edits the broadly utilized textbook, Multiple Sclerosis: Principles of Diagnosis and Treatment, helping to guide practicing physicians across the field.
  Adnan Subei, DO
  Medical Director, Multiple Sclerosis Program
  Memorial Healthcare System Neuroscience Institute
  Hollywood, Florida 
Dr. Subei is a board certified neurologist and medical director for the MS program at Memorial Healthcare System Neuroscience Institute. Has been awarded multiple fellowship grants from the American Academy of Neurology and the National Multiple Sclerosis Society and specialized in both neuro-visual and neuro-immunological disorders. He continues an active interest in research while at Memorial Healthcare where he has been since completing his fellowship at the Cleveland Clinic Mellen Center for Multiple Sclerosis Treatment and Research.
Credit for this program has expired. The accreditation information below is based on the activity release date.
Estimated Credit Hours
Postgraduate Institute for Medicine will provide up to 0.5 AMA PRA Category 1 Credits™ to learners for their participation in the web-based elements of the activity.
About PIM
The Postgraduate Institute for Medicine (PIM) has been providing trusted independent continuing education for healthcare professionals for over 35 years and is a recognized leader for jointly provided CME/CE activities. The purpose of the PIM continuing healthcare education program is to deliver effective CME/CE activities that are designed to contribute to the professional development of physicians and other healthcare professionals, support the development and function of collaborative interprofessional teams, and positively impact the delivery of healthcare. We fulfill this mission by forming successful alliances and working in collaboration to deliver impactful educational experiences that are designed to improve patient care practices.

In support of improving patient care, PIM is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team. PIM is one of a very select group of jointly accredited providers that has been awarded the highest level of a 6-year term, placing PIM among the top echelon of CME/CE providers that have demonstrated the highest levels of educational acumen in providing healthcare professionals with relevant, effective, practice-based continuing education that supports US health care quality improvement.
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